Pete, if you want to spray POR, it's very easy to do but as mentioned by TD, use a well ventilated area. POR goes down fairly smooth by brush and with a high-build primer on top should be OK for most locations. However, if you spray, use their solvent to thin (only a tiny amount of thinning is needed... if any). When I have sprayed POR I have used cheap, single-action air brushes as opposed to regular paint guns. Badger makes a model (#250 ?) that is ideal. Generic copies of the Badger unit are available at Harbor Freight and Northern Tool (among others). The cheap air brushes are easy to clean and economical enough to throw away after a few uses if you can't be bothered to completely clean up.
Regarding primer on top of POR, I have not used their new etch primer but I have used their Tie Coat primer. I hate Tie Coat. It holds their solvent in for way too long requiring many, many days for off-gassing before you can apply your top coat compatible primers and/or top coat. I have had much better luck waiting until the second coat of POR reaches that "finger drag tacky" stage and applying a fog coat of my top coat's primer. Once the POR is fully cured (24+ hours) I apply a heavy coat of high-build over the fog coat and go from there.
As with all paint, the final results come back to the amount of effort spent on preparation. Do post pictures as you work through the process.