Back when I was twenty years of age, the same rear wheel came off the 100-6 twice in one evening at highway speeds. The car barely bumped as the drum hit the pavement and the wheel passed the slowing car. Fortunately, no other traffic was nearby. The second time it was rather dark, and it took a while to find the wheel in the ditch. The knock off was still stuck to the wheel.
Someone told me that the knock off/wheel was not greased properly, as an explanation for the wheel coming off. Based on what others say above, it sounds as if the hub was installed on the wrong side of the car. Interestingly, I drove this car thousands of miles, before and after that evening, without the wheel coming off.