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Actually, I did that about 9 or 10 years ago, and it's worked pretty well. There was some experimentation to get it right, though.
Clean all the spoke pits with mineral spirits, then acetone to get all oil outta there.
Use a good quality silicone - I really like the Locktite Ultra 'Stick & seal'
Don't "slather". The silicone just needs to cover the spoke end. You don't want the silicone to protrude out of the spoke pocket - if it does there's a good chance the tire bead, when mounted, will disturb the seal.
I did this with new wheels that really shouldn't need adjustment, and have been through 1 tire change. I have no idea how it might work on older wheels. Be prepared for a few leakers - get a big C clamp and a couple of pieces of wood to get into a tire if need be. After all those years I have 1 wheel that loses 1 psi pressure every 2 weeks and can't find the leak. The others hold.
I had the same thing happen to me and after many tries to find it, it was a new tire, the side wall had two very small leaks due to a manufacturing defect. They gave me a new tire at no cost. PJ
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smilie in place of the real @
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