Hi Chris,
A while back I did quite a bit of investigation on the potential of filling key frame components with a special foam and posted my thoughts. A little while after, I had some health problems to address and never followed through. There are quite a number of benefits to filling our frames with foam, however, a major issue needed to be accepted is the extra work that would be needed to clear the foam as part of a future frame repair if needed (i.e. damage caused by an accident). I found that the issue of trapped water accelerating frame deterioration can be addressed without much difficulty and the foam would bond and seep deep into the inner frame rust to create a bond that would definitely strengthen the box. However, properly filling the frame would require access to the full access to the frame sections to be addressed and, since my car is completely finished, would require I do a major disassembly. One day when I finally decide to rebuild my motor I will address this again and probably do it.
Good luck,
Ray (64BJ8P1)