Maybe.
I have used POR on multiple parts and in various location on different car bodies. There is a lot to read online so I won't repeat it here.
My personal experiences have been good but you MUST be aware that for good results you need to follow the instructions to the letter. Use their prep chemicals. Do not expect POR to adhere well to smooth, sound sheet metal. It needs a rough surface to adhere to. Therefore, sandblast or a brade and heavily acid etch smooth surfaces or the POR will peel off in sheets/strips. Also, research how you want to prime the POR for topcoating. They have probably made acceptable primers for it by now. 15 year ago their primers were not that good and your best option was to fog coat the 2nd coat of POR (with your topcoat's primer) before the POR was completely cured.
Don't think of POR as a primer to use under your car body's topcoat, think of it as a protective coating for problem areas on the car, areas that won't be seen that often.