Elliot, new or used? Turbos have gotten a lot better than they were back in the 70s and 80s, when you were supposed to idle for a while to let the turbo slow down before you shut off the motor so you didn't burn the bearings. Still they do put more stress on the motor, and add more moving parts to wear out, if I were buying a new car with a warranty I wouldn't worry about it too much, unless you are planning to keep it long past the warranty period. If used I might steer towards a naturally aspirated motor. Easier to give better answers with more information on what you are looking at. The mechanical bits of motors are very dependable these days, and most of the problems will come from all the various electronic add ons, coil packs, sensors, fuel injection. Some known issues, older Toyotas, engine sludge issues, apparently mid 2000 Civics had some issues with cracked blocks I wasn't aware of until recently, Subaru 2.5s have head gasket issues, but the older, smaller motors go forever, bmws have plastic components in the cooling system that break cause rapid coolant lose and all sorts of problems. Lexus straight six, SC300, IS300, Supra, bulletproof, I am sure there are more, I know this stuff because these are some of the cars I was looking at when I was shopping earlier this year (actually wasn't looking at Toyotas, but wife's friend was so I researched). Look up the car you are interested in and look at the customer reviews on cars.com, msn autos, yahoo autos, that will give you some idea, but there are Lemon versions of the most reliable car (either due to some one off manufacturing issues, or a bad owner, and there are luck of the draw "bad" cars that don't give lick of trouble.