You mean other than being British designed, engineered and manufactured?
Normal head gaskets, oil leaks, the stuff you'd expect from your 4-cylinder MG or TR magnified by two more cylinders. Jag engines don't like to sit.
That said, and memory time here....there were two different head stud designs on a 4.2L. One set went almost to the main caps. Corrosion and "working" tends to make these...an issue getting out. I know of shops that have stud pullers to remove studs just to get the heads off. Usually break one or two doing it, and if they're the long ones, fun getting them out.
Cranks. Tend to bend under heavy use, but straightenable.....TuffRiding (?) tended to CAUSE warped cranks, which then required a straightening process afterwards.
4.2L was about it for bore, which made the walls a tad thin. Can't recall off the top of my bald spot whether those were more prone to cracking.
Should have lifter guide plates installed.