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I often shoot fully manual but with today's digital cameras, if I'm not wanting to continually futz with all the settings, I will often shoot in Av mode (Aperture Priority - I control F-stop), then put it in Auto ISO. That way, all I have to decide is how much depth of field I want, background bokeh, etc and let the camera pick the ISO and shutter speed. I know that's not the purest's way, but it works for me. Of course circumstances may dictate variances.