I have not personally done this, though I know some who have. John Kipping most notable. Claimed results were comperable to the dual SU's up to about 5000 rpm. Beyond that flow loss became noticable.
Beware that the Spitfire ZS manifolds come in two primary flavors, small and large runner. You will get poorer results should you attempt to fit up the HS6 to the small runner manifold.
One other caviat to consider with the Spitfire 1500 ZS manifold is that the cross runner is smaller than the 1.75 throat of an HS6. When you modify the manifold to fit up the HS6, you're going to be necking down a bit. The HS6 will also have to sit low on the manifold because of the way the cross runner isn't centered.
Some other Triumph of unrecalled name utilized the 1500 with a manifold specifically designed for the HS6, but was redrilled and mounted a CD150 ZS instead.
If you're still with me, this manifold type may be significant in that this other manifold is what John Kipping used with his HS6. He did not modify a Spitfire 1500 manifold, as I recall.