AFAIK, no glycols--which I believe are chemically related to alcohols--occur in nature (except possibly as miniscule metabolism byproducts). So, brake fluid--and antifreeze--has always been 'synthetic,' but now they're putting that on the label to capitalize on the cachet of synthetic oil (or possibly to compete with silicone BF). The whole thing smells like marketing. If 'synthetic' starts showing up on jugs of Prestone AF we'll know. Just a SWAG.
If there's no compatibility warnings on the label; e.g. 'do not mix with non-synthetic DoT 3/4' then there shouldn't be any problems mixing it with 'non-synthetic' DoT 3/4 (but I haven't done it).
On a (possibly) related note, I believe some oil labeled 'synthetic' is actually highly-refined dino oil (Castrol Syntec comes to mind). IIRC, they sued the gov't to be allowed to use the term 'synthetic,' so they must believe there's some value to labeling something as 'synthetic.'
I'm old enough to remember when 'synthetic' meant 'not as good as the real stuff.'